Tedizolid-¹³C,d₃  (Synonyms: TR 700-¹³C,d₃; Torezolid-¹³C,d₃; DA-7157-¹³C,d₃)

Tedizolid-¹³C,d₃ is the ¹³C- and deuterium labeled Tedizolid. Tedizolid (TR 700; Torezolid; DA-7157) is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[54].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

374.35

C₁₆¹³CH₁₂D₃FN₆O₃

2931763-72-1

856866-72-3

O=C1O[C@@H](CO)CN1C2=CC=C(C3=CC=C(C4=NN([13C]([2H])([2H])[2H])N=N4)N=C3)C(F)=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.  [Content Brief]

  [2]. Choi S, et al. Activity of Tedizolid Phosphate (TR-701) in Murine Models of Infection with Penicillin-resistant and Penicillin-sensitive Streptococcus pneumoniae. Antimicrob Agents Chemother. 2012 Jun 19.  [Content Brief]