2. Anti-infection
  3. Antibiotic HIV SARS-CoV
  4. Teicoplanin sodium

Teicoplanin sodium  (Synonyms: Antibiotic MDL-507 sodium; MDL-507 sodium)

Cat. No.: HY-A0097A
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Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity.

For research use only. We do not sell to patients.

Teicoplanin sodium Chemical Structure

Teicoplanin sodium Chemical Structure

CAS No. : 184539-13-7

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Teicoplanin sodium Related Antibodies

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Description

Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity[1][2].

IC50 & Target

Glycopeptide

 

In Vitro

Teicoplanin sodium shows antiviral activity with IC50s of 0.39, 1.66, 15.7 µM for HIV-luc/SARS-CoV-S pseudotyped viruses in HEK293T cells, 2019-nCoV-Spike-pseudoviruses in A549 cells, SARS-CoV-2 in Vero E6 cells, respectively[1].
Teicoplanin sodium can inhibit HIV-1 virus in human CEM cell culture with EC50 value of 17 µM[1].
The mechanism is the inhibition of the cathepsin L protease through the interaction of the teicoplanin lipophilic moiety with the enzyme and inhibits cathepsin L activity, stops the SARS-CoV release from the late endosome[1].
Teicoplanin sodium shows anti-MRSA activity with MICs of 0.5 mg/L in MRSA ATCC 43300[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Teicoplanin sodium Related Antibodies
In Vivo

Teicoplanin sodium (10, 30 mg/kg; i.v.) shows a dose-dependent decline in the total bacterial density in murine MRSA thigh infection model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20-30 g, Male CD1 mice (2 * 106 cfu/mL MRSA (43 300) 50 µL; murine thigh infection model)[2]
Dosage: 10, 30 mg/kg
Administration: I.v.; once every 12 h
Result: Showed a dose-dependent decline in the total bacterial density with the total bactericidal effect was achieved with dosages of ≥10 mg/kg/day and suppression of resistance with dosages ≥30 mg/kg/day.
Clinical Trial
Molecular Weight

1564.3-1907.7

CAS No.
SMILES

ClC1=C(OC2=CC3=CC(OC4=CC=C5C=C4Cl)=C2O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6[N][R])C=CC([C@H]([C@@H]7NC([C@](C8=CC(C9=C([C@H](C(O)=O)NC7=O)C=C(O)C=C9O[C@@H]%10[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O%10)=C(O)C=C8)([H])NC([C@]3([H])NC([C@@](C%11=CC(O)=CC(OC%12=C(O)C=CC([C@@H](N)C%13=O)=C%12)=C%11)([H])NC([C@@H](N%13)C5)=O)=O)=O)=O)O[C@@H]%14O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%14NC(C)=O)=C1.CCCCC/C=C/CCC([R])=O.CC(C)CCCCCCC([R])=O.CCCCCCCCCC([R])=O.CCC(C)CCCCCCC([R])=O.CC(C)CCCCCCCC([R])=O.[Na]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Teicoplanin sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Teicoplanin184539-13-7Antibiotic MDL-507MDL-507Antibiotic MDL507Antibiotic MDL 507MDL507MDL 507AntibioticHIVSARS-CoVHuman immunodeficiency virusSARS coronavirusHIV-1SARS-CoV1SARS-CoV2MRSAlipoglycopeptide antibioticcathepsin L proteaseInhibitorinhibitorinhibit

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