Teicoplanin sodium (Synonyms: Antibiotic MDL-507 sodium; MDL-507 sodium)

Cat. No.: HY-A0097A: FAQs
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Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity.

For research use only. We do not sell to patients.

Teicoplanin sodium Chemical Structure

CAS No. : 184539-13-7

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Other In-stock Forms of Teicoplanin sodium:

Teicoplanin

Other Forms of Teicoplanin sodium:

Teicoplanin In-stock

1 Publications Citing Use of MCE Teicoplanin sodium

•Infect Drug Resist. 2021 Dec 16;14:5449-5456. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Glycopeptide

In Vitro

Teicoplanin sodium shows antiviral activity with IC₅₀s of 0.39, 1.66, 15.7 µM for HIV-luc/SARS-CoV-S pseudotyped viruses in HEK293T cells, 2019-nCoV-Spike-pseudoviruses in A549 cells, SARS-CoV-2 in Vero E6 cells, respectively^[1].
Teicoplanin sodium can inhibit HIV-1 virus in human CEM cell culture with EC₅₀ value of 17 µM^[1].
The mechanism is the inhibition of the cathepsin L protease through the interaction of the teicoplanin lipophilic moiety with the enzyme and inhibits cathepsin L activity, stops the SARS-CoV release from the late endosome^[1].
Teicoplanin sodium shows anti-MRSA activity with MICs of 0.5 mg/L in MRSA ATCC 43300^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Teicoplanin sodium (10, 30 mg/kg; i.v.) shows a dose-dependent decline in the total bacterial density in murine MRSA thigh infection model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	20-30 g, Male CD1 mice (2 * 106 cfu/mL MRSA (43 300) 50 µL; murine thigh infection model)^[2]
Dosage:	10, 30 mg/kg
Administration:	I.v.; once every 12 h
Result:	Showed a dose-dependent decline in the total bacterial density with the total bactericidal effect was achieved with dosages of ≥10 mg/kg/day and suppression of resistance with dosages ≥30 mg/kg/day.

Clinical Trial

Molecular Weight

1564.3-1907.7

CAS No.

184539-13-7

SMILES

ClC1=C(OC2=CC3=CC(OC4=CC=C5C=C4Cl)=C2O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6[N][R])C=CC([C@H]([C@@H]7NC([C@](C8=CC(C9=C([C@H](C(O)=O)NC7=O)C=C(O)C=C9O[C@@H]%10[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O%10)=C(O)C=C8)([H])NC([C@]3([H])NC([C@@](C%11=CC(O)=CC(OC%12=C(O)C=CC([C@@H](N)C%13=O)=C%12)=C%11)([H])NC([C@@H](N%13)C5)=O)=O)=O)=O)O[C@@H]%14O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%14NC(C)=O)=C1.CCCCC/C=C/CCC([R])=O.CC(C)CCCCCCC([R])=O.CCCCCCCCCC([R])=O.CCC(C)CCCCCCC([R])=O.CC(C)CCCCCCCC([R])=O.[Na]

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vimberg V. Teicoplanin-A New Use for an Old Drug in the COVID-19 Era? Pharmaceuticals (Basel). 2021 Nov 26;14(12):1227. [Content Brief]

[2]. Ramos-Martín V, et al. Pharmacodynamics of teicoplanin against MRSA. J Antimicrob Chemother. 2017 Dec 1;72(12):3382-3389. [Content Brief]

Teicoplanin sodium Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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