2. Anti-infection
  3. Antibiotic Bacterial
  4. Telavancin

Telavancin (TD-6424) is a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). Telavancin disrupts cell membrane integrity, can be used for research of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria.

For research use only. We do not sell to patients.

Telavancin Chemical Structure

Telavancin Chemical Structure

CAS No. : 372151-71-8

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Telavancin Related Antibodies

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Description

Telavancin (TD-6424) is a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). Telavancin disrupts cell membrane integrity, can be used for research of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria[1].

IC50 & Target

Glycopeptide

 

In Vitro

Telavancin has a rapid, concentration-dependent bactericidal effect, due to disruption of cell membrane integrity[1].
Telavancin (5 μg/mL) exerts bacteriocidal effect against a MRSA strain (COL) and a VISA strain (HIP5836) at a concentration of 5 µg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Telavancin Related Antibodies
In Vivo

Telavancin has been tested in various relevant animal models of infection, namely, bacteremia (40 mg/kg/d; s.c.; twice a day, with 12 h space), endocarditis (30 mg/kg/d; i.v.; twice a day, with 12 h space; 4 d), meningitis, and pneumonia with success[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MRSA bacteremia model in neutropenic mice[1]
Dosage: 40 mg/kg
Administration: Subcutaneous injection; twice every day spaced 12 h apart 
Result: Resulted a significantly higher 14-day survival compared with vancomycin-treated animals.
Animal Model: Rabbit model of S. aureus endocarditis[1]
Dosage: 30 mg/kg
Administration: Intravenous injection; twice every day, spaced 12 h for 4 days
Result: Significantly reduced MRSA densities in all target tissues and increased the percentage of these organs rendered culture negative.
Clinical Trial
Molecular Weight

1755.63

Formula

C80H106Cl2N11O27P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC([C@H]([C@](C(N[C@@H]2C(O)=O)=O)([H])N3)O)=CC=C1OC4=CC([C@](NC([C@@H](NC5=O)CC(N)=O)=O)([H])C(N[C@](C3=O)([H])C(C=C6C(C2=CC(O)=C7CNC[P](O)(O)=O)=C7O)=CC=C6O)=O)=CC(OC8=CC=C([C@H]([C@H]5NC([C@H](NC)CC(C)C)=O)O)C=C8Cl)=C4O[C@H](O[C@@H]9CO)[C@@H]([C@H]([C@@H]9O)O)O[C@H](O[C@H]%10C)C[C@@](C)([C@@H]%10O)NCCNCCCCCCCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Telavancin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telavancin372151-71-8TD-6424TD6424TD 6424AntibioticBacterialStaphylococcus aureusantimicrobialMRSAlipoglycopeptidevancomycinsemisyntheticcomplicated skin and skin structure infectionscSSSIsInhibitorinhibitorinhibit

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