Temafloxacin hydrochloride (Synonyms: TMFX hydrochloride; TA-167; A-62254)

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Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections.

For research use only. We do not sell to patients.

Temafloxacin hydrochloride Chemical Structure

CAS No. : 105784-61-0

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Other Forms of Temafloxacin hydrochloride:

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

Quinolone

In Vitro

Temafloxacin hydrochloride (0-64 µg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of <0.004-0.5, 0.5-2 and 0.06-0.25 µg/mL for E. coli, P. aeruginosa, and S. aureus, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	E. coli (16 strains), P. aeruginosa (13 strains), and S. aureus (17 strains)
Concentration:	0-64 µg/mL
Incubation Time:	18-24 h
Result:	Inhibited E. coli (16 strains), P. aeruginosa, and S. aureus with MIC ranges of <0.004-0.5 (MIC 90%=0.06, =0.06), 0.5-2 (MIC 90%=1, MIC 50%=1) and 0.06-0.25 µg/mL (MIC 90%=0.125, MIC 50%=0.125). MIC 90% and 50% means MIC for 90% and 50% of the isolates (unit: µg/mL).

In Vivo

Temafloxacin hydrochloride (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis^[1].
Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS))^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female CF-1 mice (20-25 g) (murine pyelonephritis model)^[1].
Dosage:	6.25, 25, 100 mg/kg
Administration:	Orally; single.
Result:	Reduced the number of viable bacteria in the kidneys of mice.

Animal Model:

Female CF-1 mice (20-25 g)^[1].

Dosage:

100 mg/kg

Administration:

Subcutaneously or orally; single.

Result:

1.19 Pharmacokinetic Parameters of Temafloxacin hydrochloride in Female CF-1 mice^[1].

	C_max (µg/mL)	AUC (µg/mL•h)	T_1/2 (h)	% Urinary recovery
SC (100 mg/kg)	25.2	86.6	3.4	25.3
PO (100 mg/kg)	13.5	57.4	1.3	9.1

Molecular Weight

453.84

Formula

C₂₁H₁₉ClF₃N₃O₃

CAS No.

105784-61-0

SMILES

O=C(C1=CN(C2=CC=C(F)C=C2F)C3=C(C=C(F)C(N4CC(C)NCC4)=C3)C1=O)O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hardy DJ, et al. Comparative antibacterial activities of temafloxacin hydrochloride (A-62254) and two reference fluoroquinolones. Antimicrob Agents Chemother. 1987 Nov;31(11):1768-74. [Content Brief]

[2]. Pankey GA. Temafloxacin: an overview. Am J Med. 1991 Dec 30;91(6A):166S-172S. [Content Brief]

Temafloxacin hydrochloride Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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