2. Epigenetics Apoptosis
  3. Small Interfering RNA (siRNA) MDM-2/p53
  4. Teprasiran

Teprasiran (QPI-1002) is a small interfering RNA that temporarily inhibits p53-mediated cell death that underlies acute kidney injury (AKI).

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Teprasiran sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

RNA, (G-Am-G-Am-A-Um-A-Um-U-Um-C-Am-C-Cm-C-Um-U-Cm-A), complex with RNA (Um-G-Am-A-Gm-G-Gm-U-Gm-A-Am-A-Um-A-Um-U-Cm-U-Cm) (1:1)

Teprasiran Chemical Structure

CAS No. : 1231737-88-4

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Other Forms of Teprasiran:

Teprasiran Related Antibodies

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Description

Teprasiran (QPI-1002) is a small interfering RNA that temporarily inhibits p53-mediated cell death that underlies acute kidney injury (AKI)[1].

In Vitro

Teprasiran is a synthetic, chemically stabilized small interfering RNA (siRNA) acting through RNA interference, which temporarily inhibits p53 expression for ≈48 to 72 hours[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Teprasiran Related Antibodies
Clinical Trial
Molecular Weight

12320.00

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

RNA, (G-Am-G-Am-A-Um-A-Um-U-Um-C-Am-C-Cm-C-Um-U-Cm-A), complex with RNA (Um-G-Am-A-Gm-G-Gm-U-Gm-A-Am-A-Um-A-Um-U-Cm-U-Cm) (1:1)
SMILES

[Teprasiran]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 20 mg/mL (1.62 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.0812 mL 0.4058 mL 0.8117 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.0812 mL 0.4058 mL 0.8117 mL 2.0292 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Teprasiran Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Teprasiran1231737-88-4QPI-1002QPI1002QPI 1002Small Interfering RNA (siRNA)MDM-2/p53Teprasiran is a syntheticchemically stabilized small interfering RNA (siRNA) acting through RNA interferencewhich temporarily inhibits p53 expression for ≈48 to 72 hours[1].Inhibitorinhibitorinhibit

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