2. MAPK/ERK Pathway Apoptosis
  3. p38 MAPK Apoptosis
  4. Tetraacetylphytosphingosine

Tetraacetylphytosphingosine is a sphingolipid metabolite produced by phytosphingosine acetylation. Tetraacetylphytosphingosine exerts its inhibitory action on angiogenesis through the inhibition of MAPK activation and intracellular calcium increase. Tetraacetylphytosphingosine induces apoptosis in HaCaT cells.

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Tetraacetylphytosphingosine Chemical Structure

Tetraacetylphytosphingosine Chemical Structure

CAS No. : 13018-48-9

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Tetraacetylphytosphingosine Related Antibodies

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Description

Tetraacetylphytosphingosine is a sphingolipid metabolite produced by phytosphingosine acetylation. Tetraacetylphytosphingosine exerts its inhibitory action on angiogenesis through the inhibition of MAPK activation and intracellular calcium increase[1]. Tetraacetylphytosphingosine induces apoptosis in HaCaT cells[2].

In Vitro

Tetraacetylphytosphingosine (TAPS; 5 μM; 24 h) markedly decreases VEGF-induced chemotactic migration and capillary-like tube formation in HUVEC. Tetraacetylphytosphingosine significantly inhibits VEGF-induced proteolytic enzyme production, including MMP-2, urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1). Tetraacetylphytosphingosine also suppresseS VEGF-induced phosphorylation of p42/44 extracellular signal-regulated kinase and c-JNK[1].
In addition, Tetraacetylphytosphingosine abolished VEGF-induced intracellular calcium increase[1].
In HaCaT cells, Tetraacetylphytosphingosine co-treatment synergistically increases the level of UVB-induced apoptosis via caspase activation by regulating the level of pro-apoptotic Bax and anti-apoptotic Bcl-2[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetraacetylphytosphingosine Related Antibodies

Western Blot Analysis[1]

Cell Line: HUVEC
Concentration: 5 μM
Incubation Time: 24 h
Result: Markedly inhibits VEGF-induced proteolytic enzyme production, including MMP-2, uPA and PAI-1.
Molecular Weight

485.65

Formula

C26H47NO7
CAS No.
SMILES

CCCCCCCCCCCCCC[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](NC(C)=O)COC(C)=O
Structure Classification
Initial Source

Hansenula ciferri
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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Tetraacetylphytosphingosine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetraacetylphytosphingosine13018-48-9p38 MAPKApoptosisacetylated sphingoid baseBaxBcl-2intracellular calciumapoptosisInhibitorinhibitorinhibit

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