2. Membrane Transporter/Ion Channel
  3. Monoamine Transporter
  4. Tetrabenazine mesylate

Tetrabenazine mesylate  (Synonyms: Ro 1-9569 mesylate)

Cat. No.: HY-B0590E
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Tetrabenazine (Ro 1-9569) mesylate is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the Kd value of 1.34 nM. Tetrabenazine mesylate can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease.

For research use only. We do not sell to patients.

Tetrabenazine mesylate Chemical Structure

Tetrabenazine mesylate Chemical Structure

CAS No. : 804-53-5

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Description

Tetrabenazine (Ro 1-9569) mesylate is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the Kd value of 1.34 nM. Tetrabenazine mesylate can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease[1][2][3].

In Vivo

Tetrabenazine mesylate (subcutaneous injection, 1-10 mg/kg, once) can reduce the aggressive behavior in a dose-dependent manner and the levels of neurotransmitter molecules NE, DA and 5-HT in adult male mice[1].
Tetrabenazine mesylate (intraperitoneal injection, 0-2 mg/kg, once) has selective effects on movement which can significantly attenuate morphine-induced hypermobility but oral tremors and stereotyped behaviors in male ICR mice[2].
Tetrabenazine mesylate (intraperitoneal injection, 0.25-2 mg/kg, once a week) increases tremulous jaw movement (TJM) in a dose-dependent manner in adult male Sprague-Dawley rat[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male MAO A KO or wide type mice aged 1-2 months[1]
Dosage: 1-10 mg/kg
Administration: Subcutaneous injection; once
Result: Completely eliminated the aggressive behavior at a concentration of 5 mg/kg and significantly reduced their NE, DA and 5-HT levels.
Animal Model: Male ICR mice (10 weeks old)[2]
Dosage: 0-2 mg/kg
Administration: Intraperitoneal injection; once
Result: Attenuated the subsequent morphine-induced hypermobility after pretreatment with tetrabenazine. Reduced METH-induced increases in locomotion at 1 mg/kg.
Animal Model: Adult male Sprague-Dawley rat weighed 350-450 g[3]
Dosage: 0.25-2 mg/kg
Administration: Intraperitoneal injection; once a week
Result: Induced tremulous jaw movement (TJM) significantly at the concentration of 2 mg/kg and more motor impairments with higher doses such as 3-4 mg/kg.
Clinical Trial
Molecular Weight

413.53

Formula

C20H31NO6S
CAS No.
SMILES

CS(=O)(O)=O.O=C1[C@@H](CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3[C@]2([H])C1.[relative stereochemistry]
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Tetrabenazine mesylate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrabenazine804-53-5Ro 1-9569Monoamine TransporterVMAT2 inhibitorHuntington’s diseaseAggressionTremorInhibitorinhibitorinhibit

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