Tetraethylene glycol monomethyl ether

Name: Tetraethylene glycol monomethyl ether
Brand: MedChemExpress
SKU: HY-W018365
Rating: 4.5 (1 reviews)

Cat. No.: HY-W018365 Purity: 98.51%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Tetraethylene glycol monomethyl ether Chemical Structure

CAS No. : 23783-42-8

Size	Price	Stock	Quantity
25 g	USD 85	In-stock	Estimated Time of Arrival: December 31
50 g	USD 130	In-stock	Estimated Time of Arrival: December 31
100 g	USD 195	In-stock	Estimated Time of Arrival: December 31
500 g	USD 450	Get quote	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

208.25

Formula

C₉H₂₀O₅

CAS No.

23783-42-8

Appearance

Liquid (Density: 1.045 g/cm³)

Color

Colorless to light yellow

SMILES

COCCOCCOCCOCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (480.19 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8019 mL	24.0096 mL	48.0192 mL
5 mM	0.9604 mL	4.8019 mL	9.6038 mL
10 mM	0.4802 mL	2.4010 mL	4.8019 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.35%

Select Batch:

Data Sheet (265 KB) SDS (393 KB)

COA (239 KB) HNMR (122 KB) GC (79 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.8019 mL	24.0096 mL	48.0192 mL	120.0480 mL
	5 mM	0.9604 mL	4.8019 mL	9.6038 mL	24.0096 mL
	10 mM	0.4802 mL	2.4010 mL	4.8019 mL	12.0048 mL
	15 mM	0.3201 mL	1.6006 mL	3.2013 mL	8.0032 mL
	20 mM	0.2401 mL	1.2005 mL	2.4010 mL	6.0024 mL
	25 mM	0.1921 mL	0.9604 mL	1.9208 mL	4.8019 mL
	30 mM	0.1601 mL	0.8003 mL	1.6006 mL	4.0016 mL
	40 mM	0.1200 mL	0.6002 mL	1.2005 mL	3.0012 mL
	50 mM	0.0960 mL	0.4802 mL	0.9604 mL	2.4010 mL
	60 mM	0.0800 mL	0.4002 mL	0.8003 mL	2.0008 mL
	80 mM	0.0600 mL	0.3001 mL	0.6002 mL	1.5006 mL
	100 mM	0.0480 mL	0.2401 mL	0.4802 mL	1.2005 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.