2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Tetraethylene glycol monotosylate

Tetraethylene glycol monotosylate  (Synonyms: Tos-PEG4)

Cat. No.: HY-41541 Purity: ≥97.0%
SDS COA Handling Instructions

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Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Tetraethylene glycol monotosylate Chemical Structure

Tetraethylene glycol monotosylate Chemical Structure

CAS No. : 77544-60-6

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Based on 1 publication(s) in Google Scholar

Tetraethylene glycol monotosylate Related Antibodies

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Description

Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetraethylene glycol monotosylate Related Antibodies
Molecular Weight

348.41

Formula

C15H24O7S
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

OCCOCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥97.0%

SDS (641 KB)

COA (242 KB) HNMR (129 KB)

Handling Instructions (2659 KB)
References
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Tetraethylene glycol monotosylate Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetraethylene glycol monotosylate77544-60-6Tos-PEG4ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerADCLinkerInhibitorinhibitorinhibit

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