Tetrazine-PEG4-amine hydrochloride

Name: Tetrazine-PEG4-amine hydrochloride
Brand: MedChemExpress
SKU: HY-130977
Rating: 4.5 (1 reviews)

Cat. No.: HY-130977 Purity: 95.23%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tetrazine-PEG4-amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetrazine-PEG4-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

For research use only. We do not sell to patients.

Tetrazine-PEG4-amine hydrochloride Chemical Structure

CAS No. : 2752945-36-9

Size	Price	Stock	Quantity
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 385	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 990	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Tetrazine-PEG4-amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Tetrazine-PEG4-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC₅₀ & Target

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

470.95

Formula

C₂₀H₃₁ClN₆O₅

CAS No.

2752945-36-9

Appearance

Oil

Color

Red to purplish red

SMILES

NCCOCCOCCOCCOCCC(NCC1=CC=C(C2=NN=CN=N2)C=C1)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

Methanol : 250 mg/mL (530.84 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1234 mL	10.6168 mL	21.2337 mL
5 mM	0.4247 mL	2.1234 mL	4.2467 mL
10 mM	0.2123 mL	1.0617 mL	2.1234 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.23%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (242 KB) HNMR (263 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Methanol	1 mM	2.1234 mL	10.6168 mL	21.2337 mL	53.0842 mL
	5 mM	0.4247 mL	2.1234 mL	4.2467 mL	10.6168 mL
	10 mM	0.2123 mL	1.0617 mL	2.1234 mL	5.3084 mL
	15 mM	0.1416 mL	0.7078 mL	1.4156 mL	3.5389 mL
	20 mM	0.1062 mL	0.5308 mL	1.0617 mL	2.6542 mL
	25 mM	0.0849 mL	0.4247 mL	0.8493 mL	2.1234 mL
	30 mM	0.0708 mL	0.3539 mL	0.7078 mL	1.7695 mL
	40 mM	0.0531 mL	0.2654 mL	0.5308 mL	1.3271 mL
	50 mM	0.0425 mL	0.2123 mL	0.4247 mL	1.0617 mL
	60 mM	0.0354 mL	0.1769 mL	0.3539 mL	0.8847 mL
	80 mM	0.0265 mL	0.1327 mL	0.2654 mL	0.6636 mL
	100 mM	0.0212 mL	0.1062 mL	0.2123 mL	0.5308 mL