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  4. TFMU-ADPr diammonium

TFMU-ADPr is a universal substrate for monitoring PARG activity. TFMU-ADPr directly reports the total bar number hydrolase activity by releasing fluorophore. TFMU-ADPr is a general tool for evaluating small molecule inhibitors and exploring the regulation of ADP-ribose catabolic enzymes in vitro.

For research use only. We do not sell to patients.

TFMU-ADPr diammonium Chemical Structure

TFMU-ADPr diammonium Chemical Structure

Size Price Stock Quantity
1 mg USD 720 In-stock
5 mg USD 2150 In-stock
10 mg USD 3580 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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TFMU-ADPr diammonium Related Antibodies

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Description

TFMU-ADPr is a universal substrate for monitoring PARG activity. TFMU-ADPr directly reports the total bar number hydrolase activity by releasing fluorophore. TFMU-ADPr is a general tool for evaluating small molecule inhibitors and exploring the regulation of ADP-ribose catabolic enzymes in vitro[1].

Molecular Weight

805.50

Formula

C25H32F3N7O16P2
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(OC[C@H]2O[C@@H]([C@@H]([C@@H]2O)O)OC3=CC=C(C(C(F)(F)F)=CC(O4)=O)C4=C3)(O)=O)(O)=O)([H])N5C6=NC=NC(N)=C6N=C5.N.N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (155.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2415 mL 6.2073 mL 12.4146 mL
5 mM 0.2483 mL 1.2415 mL 2.4829 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.2415 mL 6.2073 mL 12.4146 mL 31.0366 mL
5 mM 0.2483 mL 1.2415 mL 2.4829 mL 6.2073 mL
10 mM 0.1241 mL 0.6207 mL 1.2415 mL 3.1037 mL
15 mM 0.0828 mL 0.4138 mL 0.8276 mL 2.0691 mL
20 mM 0.0621 mL 0.3104 mL 0.6207 mL 1.5518 mL
25 mM 0.0497 mL 0.2483 mL 0.4966 mL 1.2415 mL
30 mM 0.0414 mL 0.2069 mL 0.4138 mL 1.0346 mL
40 mM 0.0310 mL 0.1552 mL 0.3104 mL 0.7759 mL
50 mM 0.0248 mL 0.1241 mL 0.2483 mL 0.6207 mL
60 mM 0.0207 mL 0.1035 mL 0.2069 mL 0.5173 mL
80 mM 0.0155 mL 0.0776 mL 0.1552 mL 0.3880 mL
100 mM 0.0124 mL 0.0621 mL 0.1241 mL 0.3104 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TFMU-ADPr diammonium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TFMU-ADPr diammoniumOthersuniversal substrategeneral toolInhibitorinhibitorinhibit

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