2. Apoptosis
  3. Transferrin Receptor Ferroptosis
  4. TfR-1-IN-1

TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC50 values ​​of 0.51, 0.46, and 0.48 μM, respectively.

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TfR-1-IN-1 Chemical Structure

TfR-1-IN-1 Chemical Structure

CAS No. : 1643444-62-5

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Based on 1 publication(s) in Google Scholar

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Description

TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC50 values ​​of 0.51, 0.46, and 0.48 μM, respectively[1].

Molecular Weight

441.62

Formula

C20H12ClF2FeN2O2
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

FC1=CC=CC2=C1C=[N]3C4=CC=CC=C4[N]5=CC6=C(F)C=CC=C6[O-][Fe+3]5([Cl-])3[O-]2
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (45.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2644 mL 11.3220 mL 22.6439 mL
5 mM 0.4529 mL 2.2644 mL 4.5288 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2644 mL 11.3220 mL 22.6439 mL 56.6098 mL
5 mM 0.4529 mL 2.2644 mL 4.5288 mL 11.3220 mL
10 mM 0.2264 mL 1.1322 mL 2.2644 mL 5.6610 mL
15 mM 0.1510 mL 0.7548 mL 1.5096 mL 3.7740 mL
20 mM 0.1132 mL 0.5661 mL 1.1322 mL 2.8305 mL
25 mM 0.0906 mL 0.4529 mL 0.9058 mL 2.2644 mL
30 mM 0.0755 mL 0.3774 mL 0.7548 mL 1.8870 mL
40 mM 0.0566 mL 0.2830 mL 0.5661 mL 1.4152 mL
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TfR-1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TfR-1-IN-11643444-62-5Transferrin ReceptorFerroptosisTfRCD71TfR-1inhibitoranticancerferroptosisA2780cisMDA-MB 231HL-60Inhibitorinhibit

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