2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. TG 41

TG 41 is positive modulator of GABAA receptor. TG 41 enhances the binding both of GABA and of Flunitrazepam to rat cerebral cortical membranes.

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TG 41 Chemical Structure

TG 41 Chemical Structure

CAS No. : 850339-33-2

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TG 41 Related Antibodies

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Description

TG 41 is positive modulator of GABAA receptor. TG 41 enhances the binding both of GABA and of Flunitrazepam to rat cerebral cortical membranes[1].

In Vitro

TG41 (0.001-10 µM) increases specific [3H]GABA binding to rat cerebral cortical membranes[1].
TG41 (0.001-10 µM) increases inward Cl- currents in X. laevis oocytes expressing recombinant α1β2γ2L GABAA receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TG 41 Related Antibodies
In Vivo

TG 41 (5 mg/kg, i.v.) elicits hypnosis in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 5 mg/kg
Administration: i.v.
Result: Induced loss of the righting reflex within 8 s and for a duration of 28 min.
Molecular Weight

440.12

Formula

C18H13BrCl2N2O2
CAS No.
SMILES

O=C(C1=CN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(Br)C=C3)=N1)OCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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TG 41 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TG 41850339-33-2TG41TG-41GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAX. laevishypnosisrat cerebral corticalInhibitorinhibitorinhibit

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HY-111298
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