TG 41

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TG 41 is positive modulator of GABAA receptor. TG 41 enhances the binding both of GABA and of Flunitrazepam to rat cerebral cortical membranes.

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TG 41 Chemical Structure

CAS No. : 850339-33-2

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Description

TG 41 is positive modulator of GABAA receptor. TG 41 enhances the binding both of GABA and of Flunitrazepam to rat cerebral cortical membranes^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Oocyte	EC₅₀	0.19 μM Compound: 1n	Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes	[PMID: 15801854]

In Vitro

TG41 (0.001-10 µM) increases specific [³H]GABA binding to rat cerebral cortical membranes^[1].
TG41 (0.001-10 µM) increases inward Cl^- currents in X. laevis oocytes expressing recombinant α1β2γ2L GABAA receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TG 41 (5 mg/kg, i.v.) elicits hypnosis in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats^[1]
Dosage:	5 mg/kg
Administration:	i.v.
Result:	Induced loss of the righting reflex within 8 s and for a duration of 28 min.

Molecular Weight

440.12

Formula

C₁₈H₁₃BrCl₂N₂O₂

CAS No.

850339-33-2

SMILES

O=C(C1=CN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(Br)C=C3)=N1)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mascia MP, et al. Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors. Eur J Pharmacol. 2005 Jun 15;516(3):204-11. [Content Brief]

TG 41 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TG 41850339-33-2TG41TG-41GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAX. laevishypnosisrat cerebral corticalInhibitorinhibitorinhibit

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