TGFβ-IN-1

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TGFβ-IN-1 is an antitumor growth and metastasis agent through inhibiting the transforming growth factor‑β signaling pathway.

For research use only. We do not sell to patients.

TGFβ-IN-1 Chemical Structure

CAS No. : 883560-84-7

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

Biological Activity
Purity & Documentation
References
Customer Review

Description

TGFβ-IN-1 is an antitumor growth and metastasis agent through inhibiting the transforming growth factor‑β signaling pathway.

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	< 0.5 μM Compound: 8d	Antimigratory activity against human A549 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay Antimigratory activity against human A549 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay	[PMID: 24417479]
A549	IC₅₀	0.1 μM Compound: 8d	Antimigratory activity against human A549 cells assessed as decrease in cell migration after 12 hrs by wound healing assay Antimigratory activity against human A549 cells assessed as decrease in cell migration after 12 hrs by wound healing assay	[PMID: 24417479]
A549	IC₅₀	7.9 μM Compound: 8d	Antiproliferative activity against human A549 cells after 48 hrs by SRB assay Antiproliferative activity against human A549 cells after 48 hrs by SRB assay	[PMID: 24417479]
NCI-H1299	IC₅₀	< 0.5 μM Compound: 8d	Antimigratory activity against human H1299 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay Antimigratory activity against human H1299 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay	[PMID: 24417479]
NCI-H1299	IC₅₀	0.1 μM Compound: 8d	Antimigratory activity against human H1299 cells assessed as decrease in cell migration after 12 hrs by wound healing assay Antimigratory activity against human H1299 cells assessed as decrease in cell migration after 12 hrs by wound healing assay	[PMID: 24417479]
NCI-H1299	IC₅₀	8.07 μM Compound: 8d	Antiproliferative activity against human H1299 cells after 48 hrs by SRB assay Antiproliferative activity against human H1299 cells after 48 hrs by SRB assay	[PMID: 24417479]
PC-9	IC₅₀	5.87 μM Compound: 8d	Antiproliferative activity against human PC9 cells after 48 hrs by SRB assay Antiproliferative activity against human PC9 cells after 48 hrs by SRB assay	[PMID: 24417479]

Molecular Weight

290.36

Formula

C₁₉H₁₈N₂O

CAS No.

883560-84-7

SMILES

O=C(N(C1)CCC2=C1NC3=C2C=CC=C3)CC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zheng C, et al. Synthesis and biological evaluation of novel tetrahydro-β-carboline derivatives as antitumor growth and metastasis agents through inhibiting the transforming growth factor-β signaling pathway. J Med Chem. 2014 Feb 13;57(3):600-12. [Content Brief]

TGFβ-IN-1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TGFβ-IN-1883560-84-7TGF-β ReceptorTransforming growth factor beta receptorsInhibitorinhibitorinhibit

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