2. Metabolic Enzyme/Protease
  3. Methylenetetrahydrofolate Dehydrogenase (MTHFD)
  4. TH9028

TH9028 is an inhibitor of MTHFD2 (IC50 = 11 nM) with IC50 values against hMTHFD2, MTHFD2L, and MTHFD1 being 7.97 nM, 27 nM, and 0.5 nM, respectively.

For research use only. We do not sell to patients.

TH9028 Chemical Structure

TH9028 Chemical Structure

CAS No. : 2379556-15-5

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Description

TH9028 is an inhibitor of MTHFD2 (IC50 = 11 nM) with IC50 values against hMTHFD2, MTHFD2L, and MTHFD1 being 7.97 nM, 27 nM, and 0.5 nM, respectively[1][2].

IC50 & Target[1][2]

MTHFD2

11 nM (IC50)

hMTHFD2

7.97 nM (IC50)

MTHFD2L

27 nM (IC50)

MTHFD1

0.5 nM (IC50)

Molecular Weight

458.39

Formula

C16H18N12O5
CAS No.
SMILES

NC(NC(N)=NC1=O)=C1NC(NC2=CN=C(C(N[C@H](C(O)=O)CCC3=NN=NN3)=O)C=C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TH9028 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TH90282379556-15-5TH 9028TH-9028Methylenetetrahydrofolate Dehydrogenase (MTHFD)HL-60LCL-889Inhibitorinhibitorinhibit

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