Thalidomide-4-O-C4-NH2 hydrochloride

Cat. No.: HY-130948B Purity: 99.35%: FAQs
Data Sheet SDS COA Handling Instructions

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Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-4-O-C4-NH2 hydrochloride Chemical Structure

CAS No. : 2376990-29-1

Size	Price	Stock	Quantity
5 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 65	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-4-O-C4-NH2 hydrochloride:

Thalidomide-O-C4-NH2 Get quote

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
References
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Description

Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology.

IC₅₀ & Target

Cereblon

Molecular Weight

381.81

Formula

C₁₇H₂₀ClN₃O₅

CAS No.

2376990-29-1

Appearance

Solid

Color

White to light yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCCCN)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (130.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6191 mL	13.0955 mL	26.1910 mL
5 mM	0.5238 mL	2.6191 mL	5.2382 mL
10 mM	0.2619 mL	1.3096 mL	2.6191 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.35%

Select Batch:

Data Sheet (270 KB) SDS (478 KB)

COA (251 KB) HNMR (257 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief] [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6191 mL	13.0955 mL	26.1910 mL	65.4776 mL
	5 mM	0.5238 mL	2.6191 mL	5.2382 mL	13.0955 mL
	10 mM	0.2619 mL	1.3096 mL	2.6191 mL	6.5478 mL
	15 mM	0.1746 mL	0.8730 mL	1.7461 mL	4.3652 mL
	20 mM	0.1310 mL	0.6548 mL	1.3096 mL	3.2739 mL
	25 mM	0.1048 mL	0.5238 mL	1.0476 mL	2.6191 mL
	30 mM	0.0873 mL	0.4365 mL	0.8730 mL	2.1826 mL
	40 mM	0.0655 mL	0.3274 mL	0.6548 mL	1.6369 mL
	50 mM	0.0524 mL	0.2619 mL	0.5238 mL	1.3096 mL
	60 mM	0.0437 mL	0.2183 mL	0.4365 mL	1.0913 mL
	80 mM	0.0327 mL	0.1637 mL	0.3274 mL	0.8185 mL
	100 mM	0.0262 mL	0.1310 mL	0.2619 mL	0.6548 mL