2. PROTAC Autophagy Apoptosis
  3. E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis
  4. Thalidomide-4-O-C5-NH2 hydrochloride

Thalidomide-4-O-C5-NH2 hydrochloride 

Cat. No.: HY-138848A Purity: 96.87%
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Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-4-O-C5-NH2 hydrochloride Chemical Structure

Thalidomide-4-O-C5-NH2 hydrochloride Chemical Structure

CAS No. : 2419145-66-5

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50 mg USD 140 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-4-O-C5-NH2 hydrochloride:

Thalidomide-4-O-C5-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

  • Biological Activity

  • Purity & Documentation

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Description

Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-4-O-C5-NH2 hydrochloride Related Antibodies
Molecular Weight

395.84

Formula

C18H22ClN3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCCCCN)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (252.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5263 mL 12.6314 mL 25.2627 mL
5 mM 0.5053 mL 2.5263 mL 5.0525 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5263 mL 12.6314 mL 25.2627 mL 63.1568 mL
5 mM 0.5053 mL 2.5263 mL 5.0525 mL 12.6314 mL
10 mM 0.2526 mL 1.2631 mL 2.5263 mL 6.3157 mL
15 mM 0.1684 mL 0.8421 mL 1.6842 mL 4.2105 mL
20 mM 0.1263 mL 0.6316 mL 1.2631 mL 3.1578 mL
25 mM 0.1011 mL 0.5053 mL 1.0105 mL 2.5263 mL
30 mM 0.0842 mL 0.4210 mL 0.8421 mL 2.1052 mL
40 mM 0.0632 mL 0.3158 mL 0.6316 mL 1.5789 mL
50 mM 0.0505 mL 0.2526 mL 0.5053 mL 1.2631 mL
60 mM 0.0421 mL 0.2105 mL 0.4210 mL 1.0526 mL
80 mM 0.0316 mL 0.1579 mL 0.3158 mL 0.7895 mL
100 mM 0.0253 mL 0.1263 mL 0.2526 mL 0.6316 mL
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Thalidomide-4-O-C5-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-4-O-C5-NH22419145-66-5E3 Ligase Ligand-Linker ConjugatesAutophagyApoptosisInhibitorinhibitorinhibit

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