2. PROTAC
  3. Ligands for E3 Ligase
  4. Thalidomide-5-NH-CH2-COO(t-Bu)

Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-NH-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-NH-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

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Thalidomide-5-NH-CH2-COO(t-Bu) Chemical Structure

Thalidomide-5-NH-CH2-COO(t-Bu) Chemical Structure

CAS No. : 2412056-28-9

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Thalidomide-5-NH-CH2-COO(t-Bu) Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-NH-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-NH-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

Molecular Weight

387.39

Formula

C19H21N3O6
CAS No.
SMILES

O=C(OC(C)(C)C)CNC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Thalidomide-5-NH-CH2-COO(t-Bu) Related Classifications

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Keywords:

Thalidomide-5-NH-CH2-COO(t-Bu)2412056-28-9Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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