2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-5-O-CH2-COOH

Thalidomide-5-O-CH2-COOH is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-5-O-CH2-COOH acts as a ligand for Cereblon to recruit CRBN protein. Thalidomide-5-O-CH2-COOH is a key intermediate in the synthesis of PROTAC molecules designed based on CRBN.

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Thalidomide-5-O-CH2-COOH Chemical Structure

Thalidomide-5-O-CH2-COOH Chemical Structure

CAS No. : 2467425-53-0

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5 mg USD 120 In-stock
10 mg USD 190 In-stock
25 mg USD 385 In-stock
50 mg USD 650 In-stock
100 mg USD 1100 In-stock
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Based on 1 publication(s) in Google Scholar

Thalidomide-5-O-CH2-COOH Related Antibodies

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View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Thalidomide-5-O-CH2-COOH is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-5-O-CH2-COOH acts as a ligand for Cereblon to recruit CRBN protein. Thalidomide-5-O-CH2-COOH is a key intermediate in the synthesis of PROTAC molecules designed based on CRBN.

Molecular Weight

332.26

Formula

C15H12N2O7
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(O)COC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (376.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0097 mL 15.0485 mL 30.0969 mL
5 mM 0.6019 mL 3.0097 mL 6.0194 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0097 mL 15.0485 mL 30.0969 mL 75.2423 mL
5 mM 0.6019 mL 3.0097 mL 6.0194 mL 15.0485 mL
10 mM 0.3010 mL 1.5048 mL 3.0097 mL 7.5242 mL
15 mM 0.2006 mL 1.0032 mL 2.0065 mL 5.0162 mL
20 mM 0.1505 mL 0.7524 mL 1.5048 mL 3.7621 mL
25 mM 0.1204 mL 0.6019 mL 1.2039 mL 3.0097 mL
30 mM 0.1003 mL 0.5016 mL 1.0032 mL 2.5081 mL
40 mM 0.0752 mL 0.3762 mL 0.7524 mL 1.8811 mL
50 mM 0.0602 mL 0.3010 mL 0.6019 mL 1.5048 mL
60 mM 0.0502 mL 0.2508 mL 0.5016 mL 1.2540 mL
80 mM 0.0376 mL 0.1881 mL 0.3762 mL 0.9405 mL
100 mM 0.0301 mL 0.1505 mL 0.3010 mL 0.7524 mL
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Thalidomide-5-O-CH2-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-5-O-CH2-COOH2467425-53-0E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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