Thalidomide-5-O-CH2-COOH

Cat. No.: HY-W584518 Purity: 95.02%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Thalidomide-5-O-CH2-COOH is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-5-O-CH2-COOH acts as a ligand for Cereblon to recruit CRBN protein. Thalidomide-5-O-CH2-COOH is a key intermediate in the synthesis of PROTAC molecules designed based on CRBN.

For research use only. We do not sell to patients.

Thalidomide-5-O-CH2-COOH Chemical Structure

CAS No. : 2467425-53-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
Customer Review

Description

Molecular Weight

332.26

Formula

C₁₅H₁₂N₂O₇

CAS No.

2467425-53-0

Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(O)COC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (376.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0097 mL	15.0485 mL	30.0969 mL
5 mM	0.6019 mL	3.0097 mL	6.0194 mL
10 mM	0.3010 mL	1.5048 mL	3.0097 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.02%

Select Batch:

Data Sheet (242 KB) SDS (393 KB)

COA (247 KB) HNMR (263 KB) RP-HPLC (259 KB) MS (69 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0097 mL	15.0485 mL	30.0969 mL	75.2423 mL
	5 mM	0.6019 mL	3.0097 mL	6.0194 mL	15.0485 mL
	10 mM	0.3010 mL	1.5048 mL	3.0097 mL	7.5242 mL
	15 mM	0.2006 mL	1.0032 mL	2.0065 mL	5.0162 mL
	20 mM	0.1505 mL	0.7524 mL	1.5048 mL	3.7621 mL
	25 mM	0.1204 mL	0.6019 mL	1.2039 mL	3.0097 mL
	30 mM	0.1003 mL	0.5016 mL	1.0032 mL	2.5081 mL
	40 mM	0.0752 mL	0.3762 mL	0.7524 mL	1.8811 mL
	50 mM	0.0602 mL	0.3010 mL	0.6019 mL	1.5048 mL
	60 mM	0.0502 mL	0.2508 mL	0.5016 mL	1.2540 mL
	80 mM	0.0376 mL	0.1881 mL	0.3762 mL	0.9405 mL
	100 mM	0.0301 mL	0.1505 mL	0.3010 mL	0.7524 mL