Thalidomide-PEG2-C2-NH2 (Synonyms: Thalidomide-NH-PEG2-C2-NH2)

Cat. No.: HY-129703: FAQs
Data Sheet Handling Instructions

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Thalidomide-PEG2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Thalidomide-PEG2-C2-NH2 hydrochloride and Thalidomide-PEG2-C2-NH2 TFA) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Thalidomide-PEG2-C2-NH2 Chemical Structure

CAS No. : 2093416-32-9

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Other Forms of Thalidomide-PEG2-C2-NH2:

Thalidomide-PEG2-C2-NH2 TFA Get quote
Thalidomide-PEG2-C2-NH2 hydrochloride Get quote

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
References
Customer Review

Description

Thalidomide-PEG2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology^[1].

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

404.42

Formula

C₁₉H₂₄N₄O₆

CAS No.

2093416-32-9

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCN)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163. [Content Brief]

Thalidomide-PEG2-C2-NH2 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-PEG2-C2-NH22093416-32-9Thalidomide-NH-PEG2-C2-NH2E3 Ligase Ligand-Linker ConjugatesAutophagyApoptosisE3ligaseligand-linkerconjugatePEG3PROTACInhibitorinhibitorinhibit

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