Thalidomide-O-amido-PEG4-C2-NH2

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Thalidomide-O-amido-PEG4-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride) that retains the same biological activity.

For research use only. We do not sell to patients.

Thalidomide-O-amido-PEG4-C2-NH2 Chemical Structure

CAS No. : 1957236-22-4

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Other Forms of Thalidomide-O-amido-PEG4-C2-NH2:

Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride Get quote

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
References
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Description

Thalidomide-O-amido-PEG4-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology^[1].

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

550.56

Formula

C₂₅H₃₄N₄O₁₀

CAS No.

1957236-22-4

SMILES

O=C(NCCOCCOCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO2016105518A1.

[2]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]

[3]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]