Thalidomide-Piperazine-Piperidine hydrochloride

Name: Thalidomide-Piperazine-Piperidine hydrochloride
Brand: MedChemExpress
SKU: HY-138783A
Rating: 4.5 (1 reviews)

Cat. No.: HY-138783A Purity: 98.73%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-Piperazine-Piperidine hydrochloride Chemical Structure

CAS No. : 2599846-44-1

Size	Price	Stock	Quantity
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 810	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1300	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2080	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-Piperazine-Piperidine hydrochloride:

Thalidomide-Piperazine-Piperidine Get quote

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•Related Small Molecules:

•Related Proteins:

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

461.94

Formula

C₂₂H₂₈ClN₅O₄

CAS No.

2599846-44-1

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1NC(C(CC1)N2C(C3=CC=C(N4CCN(C5CCNCC5)CC4)C=C3C2=O)=O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 33.33 mg/mL (72.15 mM; Need ultrasonic)

DMSO : 3.6 mg/mL (7.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1648 mL	10.8239 mL	21.6478 mL
5 mM	0.4330 mL	2.1648 mL	4.3296 mL
10 mM	0.2165 mL	1.0824 mL	2.1648 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.73%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (248 KB) HNMR (193 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.1648 mL	10.8239 mL	21.6478 mL	54.1196 mL
DMSO / H₂O	5 mM	0.4330 mL	2.1648 mL	4.3296 mL	10.8239 mL
H₂O	10 mM	0.2165 mL	1.0824 mL	2.1648 mL	5.4120 mL
	15 mM	0.1443 mL	0.7216 mL	1.4432 mL	3.6080 mL
	20 mM	0.1082 mL	0.5412 mL	1.0824 mL	2.7060 mL
	25 mM	0.0866 mL	0.4330 mL	0.8659 mL	2.1648 mL
	30 mM	0.0722 mL	0.3608 mL	0.7216 mL	1.8040 mL
	40 mM	0.0541 mL	0.2706 mL	0.5412 mL	1.3530 mL
	50 mM	0.0433 mL	0.2165 mL	0.4330 mL	1.0824 mL
	60 mM	0.0361 mL	0.1804 mL	0.3608 mL	0.9020 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.