Thiamine monochloride-¹³C₄ hydrochloride

Name: Thiamine monochloride- 13 C 4 hydrochloride
Brand: MedChemExpress
SKU: HY-N0680S
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0680S Purity: 98.39%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Thiamine monochloride-¹³C₄ (hydrochloride) is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.

For research use only. We do not sell to patients.

Thiamine monochloride-<sup>13</sup>C<sub>4</sub> hydrochloride Chemical Structure

Thiamine monochloride-¹³C₄ hydrochloride Chemical Structure

CAS No. : 1257525-77-1

Size	Price	Stock	Quantity
1 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Thiamine monochloride-¹³C₄ hydrochloride:

Thiamine hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

341.24

Formula

C₈¹³C₄H₁₈Cl₂N₄OS

CAS No.

1257525-77-1

Unlabeled CAS

67-03-8

Appearance

Solid

Color

White to off-white

SMILES

[13CH3][13C]([N+](CC(C(N)=N1)=CN=C1C)=[13CH]S2)=[13C]2CCO.[Cl-].Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (293.05 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9305 mL	14.6524 mL	29.3049 mL
5 mM	0.5861 mL	2.9305 mL	5.8610 mL
10 mM	0.2930 mL	1.4652 mL	2.9305 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.39%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (250 KB) HNMR (129 KB) CNMR (126 KB) RP-HPLC (247 KB) MS (136 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Moulin M, et al. Analysis of Chlamydomonas thiamin metabolism in vivo reveals riboswitch plasticity. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14622-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.9305 mL	14.6524 mL	29.3049 mL	73.2622 mL
	5 mM	0.5861 mL	2.9305 mL	5.8610 mL	14.6524 mL
	10 mM	0.2930 mL	1.4652 mL	2.9305 mL	7.3262 mL
	15 mM	0.1954 mL	0.9768 mL	1.9537 mL	4.8841 mL
	20 mM	0.1465 mL	0.7326 mL	1.4652 mL	3.6631 mL
	25 mM	0.1172 mL	0.5861 mL	1.1722 mL	2.9305 mL
	30 mM	0.0977 mL	0.4884 mL	0.9768 mL	2.4421 mL
	40 mM	0.0733 mL	0.3663 mL	0.7326 mL	1.8316 mL
	50 mM	0.0586 mL	0.2930 mL	0.5861 mL	1.4652 mL
	60 mM	0.0488 mL	0.2442 mL	0.4884 mL	1.2210 mL
	80 mM	0.0366 mL	0.1832 mL	0.3663 mL	0.9158 mL
	100 mM	0.0293 mL	0.1465 mL	0.2930 mL	0.7326 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.