Thiobenzanilide 63T

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Thiobenzanilide 63T (63T) is a small molecule that selectively induces cancer cell death in a caspase-independent pathway. Thiobenzanilide 63T induces reactive oxygen species and lipid peroxidation. Thiobenzanilide 63T demonstrates strong cytotoxic activity against a lung-derived cancer cell line. Thiobenzanilide 63T decreases the expression of heme oxygenase (HO-1) in A549 cells.

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Thiobenzanilide 63T Chemical Structure

CAS No. : 1270966-08-9

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Description	Thiobenzanilide 63T (63T) is a small molecule that selectively induces cancer cell death in a caspase-independent pathway. Thiobenzanilide 63T induces reactive oxygen species and lipid peroxidation. Thiobenzanilide 63T demonstrates strong cytotoxic activity against a lung-derived cancer cell line. Thiobenzanilide 63T decreases the expression of heme oxygenase (HO-1) in A549 cells^[1]^[2].
Molecular Weight	456.43
Formula	C₂₀H₁₀F₆N₂S₂
CAS No.	1270966-08-9
SMILES	FC1=C(F)C(F)=CC(C(NC2=C(NC(C3=CC(F)=C(C(F)=C3)F)=S)C=CC=C2)=S)=C1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Kucinska M, et al. Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells. Toxicol In Vitro. 2016 Dec;37:148-161. [Content Brief] [2]. Kucinska M, et al. The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines. Invest New Drugs. 2019 Oct;37(5):849-864. [Content Brief]