2. PROTAC
  3. PROTAC Linkers
  4. Thiol-C2-PEG2-OH

Thiol-C2-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Thiol-C2-PEG2-OH Chemical Structure

Thiol-C2-PEG2-OH Chemical Structure

CAS No. : 56282-36-1

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50 mg USD 95 In-stock
100 mg USD 150 In-stock
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Based on 1 publication(s) in Google Scholar

Thiol-C2-PEG2-OH Related Antibodies

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Description

Thiol-C2-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thiol-C2-PEG2-OH Related Antibodies
Molecular Weight

166.24

Formula

C6H14O3S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

SCCOCCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (601.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0154 mL 30.0770 mL 60.1540 mL
5 mM 1.2031 mL 6.0154 mL 12.0308 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.0154 mL 30.0770 mL 60.1540 mL 150.3850 mL
5 mM 1.2031 mL 6.0154 mL 12.0308 mL 30.0770 mL
10 mM 0.6015 mL 3.0077 mL 6.0154 mL 15.0385 mL
15 mM 0.4010 mL 2.0051 mL 4.0103 mL 10.0257 mL
20 mM 0.3008 mL 1.5038 mL 3.0077 mL 7.5192 mL
25 mM 0.2406 mL 1.2031 mL 2.4062 mL 6.0154 mL
30 mM 0.2005 mL 1.0026 mL 2.0051 mL 5.0128 mL
40 mM 0.1504 mL 0.7519 mL 1.5038 mL 3.7596 mL
50 mM 0.1203 mL 0.6015 mL 1.2031 mL 3.0077 mL
60 mM 0.1003 mL 0.5013 mL 1.0026 mL 2.5064 mL
80 mM 0.0752 mL 0.3760 mL 0.7519 mL 1.8798 mL
100 mM 0.0602 mL 0.3008 mL 0.6015 mL 1.5038 mL
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Thiol-C2-PEG2-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiol-C2-PEG2-OH56282-36-1PROTAC LinkersInhibitorinhibitorinhibit

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