2. PROTAC
  3. PROTAC Linkers
  4. Thiol-PEG8-acid

Thiol-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Thiol-PEG8-acid Chemical Structure

Thiol-PEG8-acid Chemical Structure

CAS No. : 866889-02-3

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25 mg USD 36 In-stock
50 mg USD 59 In-stock
100 mg USD 91 In-stock
250 mg USD 212 In-stock
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Based on 1 publication(s) in Google Scholar

Thiol-PEG8-acid Related Antibodies

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Description

Thiol-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thiol-PEG8-acid Related Antibodies
Molecular Weight

458.56

Formula

C19H38O10S
CAS No.
Appearance

Liquid (Density: 1.141±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (109.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1807 mL 10.9037 mL 21.8074 mL
5 mM 0.4361 mL 2.1807 mL 4.3615 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (238 KB) HNMR (132 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1807 mL 10.9037 mL 21.8074 mL 54.5185 mL
5 mM 0.4361 mL 2.1807 mL 4.3615 mL 10.9037 mL
10 mM 0.2181 mL 1.0904 mL 2.1807 mL 5.4518 mL
15 mM 0.1454 mL 0.7269 mL 1.4538 mL 3.6346 mL
20 mM 0.1090 mL 0.5452 mL 1.0904 mL 2.7259 mL
25 mM 0.0872 mL 0.4361 mL 0.8723 mL 2.1807 mL
30 mM 0.0727 mL 0.3635 mL 0.7269 mL 1.8173 mL
40 mM 0.0545 mL 0.2726 mL 0.5452 mL 1.3630 mL
50 mM 0.0436 mL 0.2181 mL 0.4361 mL 1.0904 mL
60 mM 0.0363 mL 0.1817 mL 0.3635 mL 0.9086 mL
80 mM 0.0273 mL 0.1363 mL 0.2726 mL 0.6815 mL
100 mM 0.0218 mL 0.1090 mL 0.2181 mL 0.5452 mL
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Thiol-PEG8-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiol-PEG8-acid866889-02-3PROTAC LinkersInhibitorinhibitorinhibit

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