2. Vitamin D Related/Nuclear Receptor
  3. Thyroid Hormone Receptor
  4. THR-β agonist 2

THR-β agonist 2 is a potent agonist of THR-β. THR-β agonist 2 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021121210A1, compound 3).

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THR-β agonist 2 Chemical Structure

THR-β agonist 2 Chemical Structure

CAS No. : 2440027-77-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

THR-β agonist 2 Related Antibodies

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Description

THR-β agonist 2 is a potent agonist of THR-β. THR-β agonist 2 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021121210A1, compound 3)[1].

Molecular Weight

443.20

Formula

C18H8Cl2N6O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC1=NN(C2=CC(Cl)=C(OC3=NNC(C4=C3C=CC=C4)=O)C(Cl)=C2)C(NC1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 350 mg/mL (789.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2563 mL 11.2816 mL 22.5632 mL
5 mM 0.4513 mL 2.2563 mL 4.5126 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2563 mL 11.2816 mL 22.5632 mL 56.4079 mL
5 mM 0.4513 mL 2.2563 mL 4.5126 mL 11.2816 mL
10 mM 0.2256 mL 1.1282 mL 2.2563 mL 5.6408 mL
15 mM 0.1504 mL 0.7521 mL 1.5042 mL 3.7605 mL
20 mM 0.1128 mL 0.5641 mL 1.1282 mL 2.8204 mL
25 mM 0.0903 mL 0.4513 mL 0.9025 mL 2.2563 mL
30 mM 0.0752 mL 0.3761 mL 0.7521 mL 1.8803 mL
40 mM 0.0564 mL 0.2820 mL 0.5641 mL 1.4102 mL
50 mM 0.0451 mL 0.2256 mL 0.4513 mL 1.1282 mL
60 mM 0.0376 mL 0.1880 mL 0.3761 mL 0.9401 mL
80 mM 0.0282 mL 0.1410 mL 0.2820 mL 0.7051 mL
100 mM 0.0226 mL 0.1128 mL 0.2256 mL 0.5641 mL
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THR-β agonist 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THR-β agonist 22440027-77-8Thyroid Hormone ReceptorTHRTHR-βmetabolic diseasesobesityhyperlipidemiahypercholesterolemiadiabetesInhibitorinhibitorinhibit

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