Thrombin inhibitor 6 

Thrombin inhibitor 6 is a potent thrombin inhibitor (IC₅₀: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant^[1].

Thrombin inhibitor 6 (compound 73) is stable when incubated with CD-1 mouse and human microsomes (Clint (mouse) = 60 μL/min/mg; Clint (human)) = 17 μL/min/mg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thrombin inhibitor 6 (compound 73) (9 mg/kg, i.v.) prolongs the tail bleeding time in CD-1 mice^[1].
Thrombin inhibitor 6 (5 mg/kg, p.o.) shows F(%) of 22.8%, AUC of 713.3 h.ng/mL and C_max of 127 ng/mL in male CD-1 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

390.89

C₁₈H₁₉ClN₄O₂S

1628224-94-1

O=C1NC=CC=C1C2=NN(C(NCC3=CC=C(Cl)S3)=C2)C(C(C)(C)C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Short KM, et al. Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors. Eur J Med Chem. 2022 Oct 27;246:114855.  [Content Brief]