Thromboxane B2-d₄

Cat. No.: HY-113331S: FAQs
Data Sheet Handling Instructions

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Thromboxane B2-D4 is the deuterium labeled Thromboxane B2. Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation.

For research use only. We do not sell to patients.

Thromboxane B2-d<sub>4</sub> Chemical Structure

Thromboxane B2-d₄ Chemical Structure

CAS No. : 1346112-79-5

Size		Stock
1 mg		Get quote	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

Other Forms of Thromboxane B2-d₄:

Thromboxane B2 Get quote

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Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

374.51

Formula

C₂₀H₃₀D₄O₆

CAS No.

1346112-79-5

Unlabeled CAS

54397-85-2

SMILES

O=C(O)CC([2H])([2H])C([2H])([2H])/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H](O)C[C@@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 25 mg/mL (66.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6702 mL	13.3508 mL	26.7016 mL
5 mM	0.5340 mL	2.6702 mL	5.3403 mL
10 mM	0.2670 mL	1.3351 mL	2.6702 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6702 mL	13.3508 mL	26.7016 mL	66.7539 mL
	5 mM	0.5340 mL	2.6702 mL	5.3403 mL	13.3508 mL
	10 mM	0.2670 mL	1.3351 mL	2.6702 mL	6.6754 mL
	15 mM	0.1780 mL	0.8901 mL	1.7801 mL	4.4503 mL
	20 mM	0.1335 mL	0.6675 mL	1.3351 mL	3.3377 mL
	25 mM	0.1068 mL	0.5340 mL	1.0681 mL	2.6702 mL
	30 mM	0.0890 mL	0.4450 mL	0.8901 mL	2.2251 mL
	40 mM	0.0668 mL	0.3338 mL	0.6675 mL	1.6688 mL
	50 mM	0.0534 mL	0.2670 mL	0.5340 mL	1.3351 mL
	60 mM	0.0445 mL	0.2225 mL	0.4450 mL	1.1126 mL