Ticarcillin

Cat. No.: HY-139805: FAQs
Data Sheet Handling Instructions

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Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research.

For research use only. We do not sell to patients.

Ticarcillin Chemical Structure

CAS No. : 34787-01-4

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Other Forms of Ticarcillin:

(2S,5R,6R)-Ticarcillin disodium In-stock
Ticarcillin sodium Get quote
Ticarcillin monosodium Get quote

3 Publications Citing Use of MCE Ticarcillin

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

β-lactam

In Vitro

Ticarcillin treatment (10 mg/L; 18 h) shows antibacterial activities^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Ps. aeruginosa
Concentration:	10 mg/L
Incubation Time:	18 hours
Result:	Showed the MIC for Ticarcillin against strain between 6.3-12.5 mg/L.

In Vivo

Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows a dose-dependent antibacterial effect^[2].
Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows excellent pharmacokinetic assessment^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss type male mice injected with Ps. aeruginosa^[2]
Dosage:	50, 100, 200 mg/kg
Administration:	Subcutaneous injection; 50, 100, 200 mg/kg; once
Result:	Increased effect significantly (0.001 < P < 0.0025) with increasing dose.

Animal Model:

Swiss type male mice injected with Ps. aeruginosa^[2]

Dosage:

50, 100, 200 mg/kg

Administration:

Subcutaneous injection; 50, 100, 200 mg/kg; once

Result:

	Dose (mg/kg)	AUC^a (mg/kg)	K_el^b (h^-1)	T_1/2 (min)
Ticarcillin	50	8.76 (0.72)	1.57 (0.18)	26
	100	26.14 (0.60)	1.53 (0.11)	27
	200	54.56 (2.90)	1.47 (0.12)	28

Molecular Weight

384.43

Formula

C₁₅H₁₆N₂O₆S₂

CAS No.

34787-01-4

SMILES

OC([C@H](C1=CSC=C1)C(N[C@H]2[C@]3([H])N(C2=O)[C@H](C(C)(S3)C)C(O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cecile Formosa, et al. Nanoscale effects of antibiotics on P. aeruginosa. Nanomedicine. 2012 Jan;8(1):12-6. [Content Brief]

[2]. G B van der Voet, et al. Comparison of the antibacterial activity of azlocillin and ticarcillin in vitro and in irradiated neutropenic mice. J Antimicrob Chemother. 1985 Nov;16(5):605-13. [Content Brief]

[3]. Oriel Spierer, et al. Comparative activity of antimicrobials against Pseudomonas aeruginosa, Achromobacter xylosoxidans and Stenotrophomonas maltophilia keratitis isolates. Br J Ophthalmol. 2018 May;102(5):708-712. [Content Brief]

Ticarcillin Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ticarcillin34787-01-4AntibioticBacterialantibacterial agentgram-negative bacteriaATCC 27853Ps. aeruginosaInhibitorinhibitorinhibit

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