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Tilogotamab  (Synonyms: GEN-1029; HexaBody-DR5/DR5; Hx-DR5-01/05)

Cat. No.: HY-P99559 Purity: 99.31%
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Tilogotamab (GEN-1029) is an agonistic hexamer formation-enhanced mixture of two antibodies that target two separate epitopes on death receptor type 5 (DR5). Tilogotamab specifically binds to and activates DR5. Tilogotamab can be used for the research of multiple myeloma (MM).

For research use only. We do not sell to patients.

CAS No. : 2109731-10-2

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Description

Tilogotamab (GEN-1029) is an agonistic hexamer formation-enhanced mixture of two antibodies that target two separate epitopes on death receptor type 5 (DR5). Tilogotamab specifically binds to and activates DR5. Tilogotamab can be used for the research of multiple myeloma (MM)[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
In Vivo

Tilogotamab (20 μg/mL; 24 h) induces potent cytotoxicity of primary MM cells[1].
Tilogotamab is a mixture of 2 noncompeting DR5-specific immunoglobulin G1 (IgG1) antibodies, each with an E430G mutation in the Fc domain. This mutation enhances Fc-Fc interactions, resulting in antibody hexamerization, followed by FcγR-independent clustering of DR5 molecules[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tilogotamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tilogotamab2109731-10-2GEN-1029 HexaBody-DR5/DR5 Hx-DR5-01/05GEN1029GEN 1029OthersDR5death receptor type 5multiple myelomaInhibitorinhibitorinhibit

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