2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride

TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride 

Cat. No.: HY-156691A
Handling Instructions

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TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride is a Drug-Linker Conjugates for ADC. TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride is the hydrochloride form of TLR7/8 agonist 4 hydroxy-PEG6-acid. TLR7/8 agonist 4 hydroxy-PEG6-acid consists of TLR7/8 agonist 4 (HY-139017) and a linker Hydroxy-PEG6-acid (HY-133050), and can be used for synthesis of ADCs.

For research use only. We do not sell to patients.

TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride Chemical Structure

TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride Chemical Structure

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1 mg USD 500 In-stock
5 mg USD 1200 In-stock
10 mg USD 1900 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride:

TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride Related Antibodies

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Description

TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride is a Drug-Linker Conjugates for ADC. TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride is the hydrochloride form of TLR7/8 agonist 4 hydroxy-PEG6-acid. TLR7/8 agonist 4 hydroxy-PEG6-acid consists of TLR7/8 agonist 4 (HY-139017) and a linker Hydroxy-PEG6-acid (HY-133050), and can be used for synthesis of ADCs[1].

Molecular Weight

697.26

Formula

C33H53ClN6O8
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCOCCOCCOCCOCCOCCOCCN1CCN(CC1)C2=CC3=C(N=C(C4=C3NC(CCCC)=N4)N)C=C2)O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (71.71 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4342 mL 7.1709 mL 14.3419 mL
5 mM 0.2868 mL 1.4342 mL 2.8684 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4342 mL 7.1709 mL 14.3419 mL 35.8546 mL
5 mM 0.2868 mL 1.4342 mL 2.8684 mL 7.1709 mL
10 mM 0.1434 mL 0.7171 mL 1.4342 mL 3.5855 mL
15 mM 0.0956 mL 0.4781 mL 0.9561 mL 2.3903 mL
20 mM 0.0717 mL 0.3585 mL 0.7171 mL 1.7927 mL
25 mM 0.0574 mL 0.2868 mL 0.5737 mL 1.4342 mL
30 mM 0.0478 mL 0.2390 mL 0.4781 mL 1.1952 mL
40 mM 0.0359 mL 0.1793 mL 0.3585 mL 0.8964 mL
50 mM 0.0287 mL 0.1434 mL 0.2868 mL 0.7171 mL
60 mM 0.0239 mL 0.1195 mL 0.2390 mL 0.5976 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7/8 agonist 4 hydroxy-PEG6-acidDrug-Linker Conjugates for ADCcancerADCsTLR7/8 agonistInhibitorinhibitorinhibit

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