2. Immunology/Inflammation
  3. Toll-like Receptor (TLR) NOD-like Receptor (NLR)
  4. TLR7 agonist 27

TLR7 agonist 27 (compound 24) is a potent TLR7 agonist with an EC50 of 238.1 nM. TLR7 agonist 27 shows weak agonistic activity against NOD2 (nucleotide-binding oligomerization domain 2) (EC50 of 6.2 μM). TLR7 agonist 27 is a potent immunostimulant, and can be used as a vaccine adjuvant and/or immunotherapeutic.

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TLR7 agonist 27 Chemical Structure

TLR7 agonist 27 Chemical Structure

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TLR7 agonist 27 Related Antibodies

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Description

TLR7 agonist 27 (compound 24) is a potent TLR7 agonist with an EC50 of 238.1 nM. TLR7 agonist 27 shows weak agonistic activity against NOD2 (nucleotide-binding oligomerization domain 2) (EC50 of 6.2 μM). TLR7 agonist 27 is a potent immunostimulant, and can be used as a vaccine adjuvant and/or immunotherapeutic[1].

IC50 & Target[1]

TLR7

238.1 nM (EC50)

NOD2

6156 nM (EC50)

Molecular Weight

945.07

Formula

C47H64N10O11
SMILES

COC1=C(O)C=CC(/C=C/C(NCC(N[C@H](C(N[C@@H](C(OCC)=O)CCC(NCCCCCCNC(C(C=C2)=CC=C2CN3C4=NC(OCCCC)=NC(N)=C4N=C3O)=O)=O)=O)C(C)C)=O)=O)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TLR7 agonist 27 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7 agonist 27Toll-like Receptor (TLR)NOD-like Receptor (NLR)TLR7 agonistNOD2immunostimulantvaccine adjuvantInhibitorinhibitorinhibit

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