TLR8 agonist 2 hydrochloride 

TLR8 agonist 2 hydrochloride is a potent and selective TLR8 agonist with an EC₅₀ of 3 nM for human TLR8. TLR8 agonist 2 hydrochloride shows less active against human TLR7 (EC₅₀ of 33.33 μM)^[1].

TLR8 agonist 2 (Example 1) increases the levels of TNF-α, IL-12p40, IFN-γ, and IFN-α with EC₅₀ values 105 nM, 26 nM, 29 nM, and 2800 nM, respectively, in human peripheral blood mononuclear cells (hPBMC)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

The pharmacokinetic related parameters of TLR8 agonist 2 (Example 1) in mice administered with the intravenous administration of 1 mg/kg and the oral administration of 5 mg/kg are detected. The T_1/2 of TLR8 agonist 2 are 0.25 h (1 mg/kg i.v.) and 0.5 h (5 mg/kg p.o.), the AUC_last are 450 ng/mL*hr (i.v.) and 624 ng/mL*hr (p.o.). And for oral administration, the bioavailability (%F) is 27.7%^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₁₆H₂₂N₈.xHCl

2412937-65-4

CCCC[C@@](CC1=NN=CN1)(C)NC2=NC(N)=NC3=C2C=CN=C3.[x].Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhe Cai, et al. Tlr8 agonist. WO2020057604A1.