TLR8 agonist 7

Cat. No.: HY-161629: FAQs
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TLR8 agonist 7 (Compound II-36) is an agonist for Toll-like receptor 8 (TLR8) with EC₅₀ <250 nM. TLR8 agonist 7 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC₅₀ <1 μM. TLR8 agonist 7 exhibits antitumor activity in MC38-HER2 xenograft mouse model with a tumor growth inhibition (TGI) rate of 98%.

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TLR8 agonist 7 Chemical Structure

CAS No. : 3034750-26-7

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Biological Activity
Purity & Documentation
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Description

IC₅₀ & Target

TLR8

Molecular Weight

1094.13

Formula

C₅₄H₆₃N₉O₁₆

CAS No.

3034750-26-7

SMILES

O[C@H]([C@@H](C(O)=O)O1)[C@H](O)[C@@H](O)[C@@H]1OC2=C(NC(CNC(CCCCCN3C(C=CC3=O)=O)=O)=O)C=C(COC(N4CC5=CC(NC(C6(CC6)C7=CC=C8C(N=C(N)CC(C(N(CCC)CCO)=O)=C8)=C7)=O)=CN=C5CC4)=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang W, et al., Benzazepine derivative, conjugate containing same, and use thereof. WO2024067841A1.

TLR8 agonist 7 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR8 agonist 73034750-26-7Toll-like Receptor (TLR)BT474MCF-7MDA-AB-468NUGC-4MDA-AB-175VIILS180AsPC-1MC38-HER2colon cancerInhibitorinhibitorinhibit

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