2. Cell Cycle/DNA Damage PROTAC
  3. CDK PROTACs
  4. TMX-2138

TMX-2138 is a CDKs PROTAC degrader, with IC50s of 8.7 nM, 10.9 nM, 7.0 nM and 25.7 nM for CDK1/cyclinB, CDK2/cyclinA, CDK5/p25 and CDK9/cyclinT1, respectively. TMX-2138 promotes ubiquitination and degradation of CDKs. TMX-2138 can be used for the research of ovarian cancer (Pink: CDKs ligand (HY-151071); Blue: E3 ligase CRBN ligand (HY-14658); Black: linker (HY-W008352)).

For research use only. We do not sell to patients.

TMX-2138 Chemical Structure

TMX-2138 Chemical Structure

CAS No. : 2488892-07-3

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TMX-2138 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

TMX-2138 is a CDKs PROTAC degrader, with IC50s of 8.7 nM, 10.9 nM, 7.0 nM and 25.7 nM for CDK1/cyclinB, CDK2/cyclinA, CDK5/p25 and CDK9/cyclinT1, respectively. TMX-2138 promotes ubiquitination and degradation of CDKs. TMX-2138 can be used for the research of ovarian cancer (Pink: CDKs ligand (HY-151071); Blue: E3 ligase CRBN ligand (HY-14658); Black: linker (HY-W008352))[1].

IC50 & Target[1]

CDK1/cyclinB

8.7 nM (IC50)

CDK2/cyclinA

10.9 nM (IC50)

Cdk5/p25

7.0 nM (IC50)

CDK9/cyclinT1

25.7 nM (IC50)

CDK4/cyclinD1

901 nM (IC50)

CDK6/cyclinD1

465 nM (IC50)

CDK7/cyclin H

286 nM (IC50)

Molecular Weight

956.79

Formula

C40H43BrFN9O11S
CAS No.
SMILES

O=C(C1=C(NC2=NC(NC3=CC=C(S(=O)(NCCOCCOCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=O)C=C3)=NC=C2Br)C=CC=C1F)N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TMX-2138 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TMX-21382488892-07-3TMX2138TMX 2138CDKPROTACsCyclin dependent kinaseOvarian cancerOVCAR8Cell cycleAntiproliferative.Inhibitorinhibitorinhibit

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