2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. TN14003

TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TN14003 Chemical Structure

TN14003 Chemical Structure

CAS No. : 368874-31-1

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TN14003 Related Antibodies

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Description

TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity[1].

In Vivo

TN14003 (7.5 mg/kg, intraperitoneal injection, 5 days per week) inhibits HER2 tumor growth by reducingangiogenesis and myofibroblast content[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

2037.42

Formula

C90H141N33O18S2
CAS No.
Sequence

Arg-Arg-{Ala-(2-Naph)}-Cys-Tyr-{Cit}-Lys-Lys-Pro-Tyr-Arg-{Cit}-Cys-Arg-NH2 (Disulfide bridge: Cys4-Cys13)
Sequence Shortening

RR-{Ala-(2-Naph)}CY-{Cit}-KKPYR-{Cit}-CR-NH2 (Disulfide bridge: Cys4-Cys13)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TN14003 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TN14003368874-31-1TN 14003TN-14003CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCR4CXCL12HER2patient-derived xenografts (PDX)Inhibitorinhibitorinhibit

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HY-131374
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