2. Apoptosis NF-κB
  3. TNF Receptor NF-κB Apoptosis
  4. TNF-α (31-45), human

TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis.

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TNF-α (31-45), human Chemical Structure

TNF-α (31-45), human Chemical Structure

CAS No. : 144796-71-4

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1 mg USD 75 In-stock
5 mg USD 185 In-stock
10 mg USD 300 In-stock
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Based on 5 publication(s) in Google Scholar

Other Forms of TNF-α (31-45), human:

TNF-α (31-45), human Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis[1][2][3].

IC50 & Target[1][2]

NF-κB

 

In Vitro

TNF-α (31-45), human (5 μM; for 1 h) promotes cisplatin resistance by the activation of the NF-kB pathway. TNF-α (31-45), human does not alter RPS3 expression levels[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TNF-α (31-45), human Related Antibodies
Molecular Weight

1667.87

Formula

C69H122N26O22
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

RRANALLANGVELRD
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (29.98 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5996 mL 2.9978 mL 5.9957 mL
5 mM 0.1199 mL 0.5996 mL 1.1991 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.77%

COA (246 KB) LCMS (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5996 mL 2.9978 mL 5.9957 mL 14.9892 mL
5 mM 0.1199 mL 0.5996 mL 1.1991 mL 2.9978 mL
10 mM 0.0600 mL 0.2998 mL 0.5996 mL 1.4989 mL
15 mM 0.0400 mL 0.1999 mL 0.3997 mL 0.9993 mL
20 mM 0.0300 mL 0.1499 mL 0.2998 mL 0.7495 mL
25 mM 0.0240 mL 0.1199 mL 0.2398 mL 0.5996 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TNF-α (31-45), human Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNF-α (31-45), human144796-71-4TNF ReceptorNF-κBApoptosisTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBproinflammatory cytokinenecrosisinvasionmetastasisInhibitorinhibitorinhibit

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