1. Others Metabolic Enzyme/Protease Neuronal Signaling
  2. Isotope-Labeled Compounds COMT Amyloid-β
  3. Tolcapone-d7

Tolcapone-d7 is a deuterium labeled Tolcapone. Tolcapone is a selective, potent and orally active COMT inhibitor. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis and protect against extracellular toxicity induced by the aggregation of both proteins in PC12 cells[1][2].

For research use only. We do not sell to patients.

Tolcapone-d<sub>7</sub> Chemical Structure

Tolcapone-d7 Chemical Structure

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Description

Tolcapone-d7 is a deuterium labeled Tolcapone. Tolcapone is a selective, potent and orally active COMT inhibitor. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis and protect against extracellular toxicity induced by the aggregation of both proteins in PC12 cells[1][2].

IC50 & Target

COMT[1]
α-syn and Aβ42 oligomerization, fibrillogenesis[2]

Molecular Weight

280.28

Formula

C14H4D7NO5

Unlabeled CAS

134308-13-7

SMILES

O=C(C1=CC(O)=C(O)C([N+]([O-])=O)=C1)C2=C([2H])C([2H])=C(C([2H])([2H])[2H])C([2H])=C2[2H]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tolcapone-d7
Cat. No.:
HY-17406S
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