Topiramate D12  (Synonyms: McN 4853 D12 ; RWJ 17021 D12)

Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase^[1][2][3].

351.44

C₁₂H₉D₁₂NO₈S

1279037-95-4

97240-79-4

Solid

White to off-white

NS(OC[C@]12[C@](OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])O2)([H])[C@@]3([H])[C@@](OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])O3)([H])CO1)(=O)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Kaminski RM, et al. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46(8):1097-104.  [Content Brief]

  [2]. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56.  [Content Brief]

  [3]. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7.  [Content Brief]