2. PROTAC
  3. PROTAC Linkers
  4. Tos-PEG4-THP

Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523).

For research use only. We do not sell to patients.

Tos-PEG4-THP Chemical Structure

Tos-PEG4-THP Chemical Structure

CAS No. : 86259-89-4

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100 mg USD 75 In-stock
250 mg USD 130 In-stock
500 mg USD 220 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Tos-PEG4-THP Related Antibodies

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  • Purity & Documentation

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Description

Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1].

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tos-PEG4-THP Related Antibodies
Molecular Weight

432.53

Formula

C20H32O8S
CAS No.
Appearance

Liquid (Density: 1.21±0.1 g/cm3)

Color

Colorless to light yellow

SMILES

O=S(C1=CC=C(C)C=C1)(OCCOCCOCCOCCOC2CCCCO2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (231.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3120 mL 11.5599 mL 23.1198 mL
5 mM 0.4624 mL 2.3120 mL 4.6240 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥95.0%

COA (242 KB) HNMR (242 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.3120 mL 11.5599 mL 23.1198 mL 57.7995 mL
5 mM 0.4624 mL 2.3120 mL 4.6240 mL 11.5599 mL
10 mM 0.2312 mL 1.1560 mL 2.3120 mL 5.7799 mL
15 mM 0.1541 mL 0.7707 mL 1.5413 mL 3.8533 mL
20 mM 0.1156 mL 0.5780 mL 1.1560 mL 2.8900 mL
25 mM 0.0925 mL 0.4624 mL 0.9248 mL 2.3120 mL
30 mM 0.0771 mL 0.3853 mL 0.7707 mL 1.9266 mL
40 mM 0.0578 mL 0.2890 mL 0.5780 mL 1.4450 mL
50 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1560 mL
60 mM 0.0385 mL 0.1927 mL 0.3853 mL 0.9633 mL
80 mM 0.0289 mL 0.1445 mL 0.2890 mL 0.7225 mL
100 mM 0.0231 mL 0.1156 mL 0.2312 mL 0.5780 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tos-PEG4-THP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tos-PEG4-THP86259-89-4PROTAC LinkersPEGPROTAClinkerE3ubiquitinligaseproteinInhibitorinhibitorinhibit

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Tos-PEG4-THP
Cat. No.:
HY-130819
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