2. Anti-infection
  3. Antibiotic Bacterial
  4. Tosufloxacin

Tosufloxacin (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Tosufloxacin tosylate hydrate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Tosufloxacin Chemical Structure

Tosufloxacin Chemical Structure

CAS No. : 100490-36-6

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Tosufloxacin Related Antibodies

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Description

Tosufloxacin (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2].

IC50 & Target

Quinolone

 

In Vitro

Tosufloxacin tosylate hydrate (T-3262) (0.05-3.13 μg/mL; 18 h) shows antibacterial activities against S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tosufloxacin Related Antibodies

Cell Viability Assay[2]

Cell Line: S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens
Concentration: 0.05-3.13 μg/mL
Incubation Time: 18 hours
Result: Showed MIC90s (MICs for 90% of the isolates tested) ranging from 0.05 to 1.56 μg/mL for S. aureus, Staphylococcus epidermidis, streptococci, and enterococci.
Showed MIC90s of 1.56, 3.13, and 0.20 μg/mL for Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens, respectively.
In Vivo

Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity against S. aureus, E. coli, and P. aeruginosa in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Slc:ICR mice infected with S. aureus[2]
Dosage: 1.27-2.15 mg/kg
Administration: Oral gavage; 1.27-2.15 mg/kg; once
Result: Showed 50% effective dose (ED50) of 1.62 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
Animal Model: Male Slc:ICR mice infected with E. coli[2]
Dosage: 0.16-0.30 mg/kg
Administration: Oral gavage; 0.16-0.30 mg/kg; once
Result: Showed 50% effective dose (ED50) of 0.22 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
Animal Model: Male Slc:ICR mice infected with P. aeruginosa[2]
Dosage: 7.66-13.39 mg/kg
Administration: Oral gavage; 7.66-13.39 mg/kg; once
Result: Showed 50% effective dose (ED50) of 10.13 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.78 μg/mL.
Molecular Weight

404.34

Formula

C19H15F3N4O3
CAS No.
SMILES

O=C(C1=CN(C2=CC=C(F)C=C2F)C3=C(C=C(F)C(N4CC(N)CC4)=N3)C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tosufloxacin Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tosufloxacin100490-36-6A-61827A61827A 61827AntibioticBacterialantibacterial activitygram-positive bacteriagram-negative bacteriaS. aureusStaphylococcus epidermidisstreptococcienterococciBacteroides fragilisClostridium difficileClostridium perfringensInhibitorinhibitorinhibit

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