Tosufloxacin (Synonyms: A-61827)

Cat. No.: HY-B1802: FAQs
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Tosufloxacin (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Tosufloxacin tosylate hydrate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Tosufloxacin Chemical Structure

CAS No. : 100490-36-6

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Other In-stock Forms of Tosufloxacin:

Tosufloxacin tosylate hydrate

Other Forms of Tosufloxacin:

2 Publications Citing Use of MCE Tosufloxacin

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Biological Activity
Purity & Documentation
References
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Description

Tosufloxacin (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria^[1]^[2].

IC₅₀ & Target

Quinolone

In Vitro

Tosufloxacin tosylate hydrate (T-3262) (0.05-3.13 μg/mL; 18 h) shows antibacterial activities against S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens
Concentration:	0.05-3.13 μg/mL
Incubation Time:	18 hours
Result:	Showed MIC₉₀s (MICs for 90% of the isolates tested) ranging from 0.05 to 1.56 μg/mL for S. aureus, Staphylococcus epidermidis, streptococci, and enterococci. Showed MIC₉₀s of 1.56, 3.13, and 0.20 μg/mL for Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens, respectively.

In Vivo

Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity against S. aureus, E. coli, and P. aeruginosa in vivo^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Slc:ICR mice infected with S. aureus^[2]
Dosage:	1.27-2.15 mg/kg
Administration:	Oral gavage; 1.27-2.15 mg/kg; once
Result:	Showed 50% effective dose (ED₅₀) of 1.62 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.0125 μg/mL.

Animal Model:	Male Slc:ICR mice infected with E. coli^[2]
Dosage:	0.16-0.30 mg/kg
Administration:	Oral gavage; 0.16-0.30 mg/kg; once
Result:	Showed 50% effective dose (ED₅₀) of 0.22 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.0125 μg/mL.

Animal Model:	Male Slc:ICR mice infected with P. aeruginosa^[2]
Dosage:	7.66-13.39 mg/kg
Administration:	Oral gavage; 7.66-13.39 mg/kg; once
Result:	Showed 50% effective dose (ED₅₀) of 10.13 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.78 μg/mL.

Molecular Weight

404.34

Formula

C₁₉H₁₅F₃N₄O₃

CAS No.

100490-36-6

SMILES

O=C(C1=CN(C2=CC=C(F)C=C2F)C3=C(C=C(F)C(N4CC(N)CC4)=N3)C1=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chu DT, et al. Synthesis and biological properties of A-71497: a prodrug of tosufloxacin. Drugs Exp Clin Res. 1990;16(9):435-43. [Content Brief]

[2]. Fujimaki K, et al. In vitro and in vivo antibacterial activities of T-3262, a new fluoroquinolone. Antimicrob Agents Chemother. 1988 Jun;32(6):827-33. [Content Brief]

Tosufloxacin Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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