2. Immunology/Inflammation
  3. Thrombopoietin Receptor
  4. Totrombopag

Totrombopag is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag can be used to study platelet production and megakaryocyte biology.

For research use only. We do not sell to patients.

Totrombopag Chemical Structure

Totrombopag Chemical Structure

CAS No. : 376592-42-6

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Other Forms of Totrombopag:

Totrombopag Related Antibodies

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Description

Totrombopag is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag can be used to study platelet production and megakaryocyte biology[1].

Molecular Weight

466.49

Formula

C25H22N8O2
CAS No.
SMILES

O=C1N(C2=CC=C(C)C(C)=C2)N=C(C1/N=N/C3=C(O)C(C4=CC(C5=NN=NN5)=CC=C4)=CC=C3)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Totrombopag Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Totrombopag376592-42-6Thrombopoietin Receptorthrombopoietin receptoragonistJAK2STAT5megakaryocyte biologyInhibitorinhibitorinhibit

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