2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. TP-050

TP-050 is a potent, orally active and selective NMDAR agonist with an EC50 value of 0.51 µM and 9.6 µM for GluN2A and GluN2D, respecticely. TP-050 can cross the blood-brain barrier (BBB). TP-050 induces hippocampal long-term (LPT) potentiation enhancemen and enhances neuronal signal transmission.

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TP-050 Chemical Structure

TP-050 Chemical Structure

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TP-050 Related Antibodies

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Description

TP-050 is a potent, orally active and selective NMDAR agonist with an EC50 value of 0.51 µM and 9.6 µM for GluN2A and GluN2D, respecticely. TP-050 can cross the blood-brain barrier (BBB). TP-050 induces hippocampal long-term (LPT) potentiation enhancemen and enhances neuronal signal transmission[1].

IC50 & Target

EC50: 0.51 µM (GluN2A) and 9.6 µM (GluN2D)[1]
In Vivo

TP-050 (10 mg/kg; p.o.) induces neuroplastic enhancement in Sprague-Dawley rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1]
Dosage: 10 mg/kg
Administration: Oral administration
Result: Induced LTP enhancement 24 h after oral administration of 10 mg/kg.
Molecular Weight

380.78

Formula

C16H15ClF2N6O
SMILES

CC1=CN(C(C2=CC(CN3N=C(C=C3Cl)C(F)F)=NN12)=O)[C@@H](CC#N)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TP-050 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TP-050TP050TP 050iGluRIonotropic glutamate receptorsoralblood-brain barrierhippocampal long-termneuronal signal transmissionInhibitorinhibitorinhibit

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