TP-TRFS 

TP-TRFS is a highly selective and the first two-photon fluorescent probe of thioredoxin reductase (TrxR)^[1].

TP-TRFS (10 μM) exhibits weak fluorescence (Φ = 0.57%, absolute quantum yield), and after TP-TRFS (10 μM)) is incubated with TCEP (1 mM), a dramatic fluorescence increment at 490 nm is observed (Φ= 22.31%, absolute quantum yield) and the fluorescence intensity of the test system increased by B40-fold within 3 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TP-TRFS has the ability to visualize the TrxR activity in vivo, and also provides a mechanistic link between stroke and the loss of TrxR function, which may open up a new therapeutic window of stroke via the regulation of TrxR function^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

333.43

C₁₆H₁₅NO₃S₂

2937819-61-7

CC(C1=CC=C2C=C(C=CC2=C1)NC(OC3CSSC3)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jintao Zhao, et al. Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe. Chem Commun (Camb). 2020 Nov 12;56(90):14075-14078.  [Content Brief]