2. TGF-beta/Smad
  3. TGF-β Receptor
  4. TP0427736

TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells.

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TP0427736 Chemical Structure

TP0427736 Chemical Structure

CAS No. : 864374-00-5

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TP0427736 Related Antibodies

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1 Publications Citing Use of MCE TP0427736

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

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Description

TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells[1].

Molecular Weight

298.39

Formula

C14H10N4S2
CAS No.
SMILES

CC1=CSC(C2=C(NC=N2)C3=CC=C4N=CSC4=C3)=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TP0427736 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TP0427736864374-00-5TP 0427736TP-0427736TGF-β ReceptorTransforming growth factor beta receptorsALK5 InhibitorSmad2 phosphorylationAndrogenic alopeciaA549Inhibitorinhibitorinhibit

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TP0427736
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HY-118528
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