2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Trandolapril hydrochloride

Trandolapril hydrochloride  (Synonyms: RU44570 hydrochloride)

Cat. No.: HY-B0592A
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Trandolapril (RU44570) hydrochloride is a nonsulfhydryl proagent that is hydrolysed to the active diacid Trandolapril hydrochlorideat. Trandolapril hydrochloride is an orally active angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI).

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Trandolapril hydrochloride Chemical Structure

Trandolapril hydrochloride Chemical Structure

CAS No. : 87725-72-2

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Description

Trandolapril (RU44570) hydrochloride is a nonsulfhydryl proagent that is hydrolysed to the active diacid Trandolapril hydrochlorideat. Trandolapril hydrochloride is an orally active angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI)[1].

IC50 & Target

Target: Angiotensin-converting Enzyme (ACE)[1]
In Vivo

Trandolapril hydrochloride (3 mg/kg/day; p.o.; 7 d) reduces renal fibrosis in obstructive nephropathy in mice, by inhibiting renal interstitial matrix expression and myofibroblast activation, decreasing renal proinflammatory cytokine RANTES and TNF-α level[2].
Trandolapril hydrochloride (0.3 mg/kg/day; p.o.; 4 weeks) improves arterial mechanics in rats, prevents arterial hypertrophy, collagen and cellular fibronectin accumulation[3].
randolapril (0.3 mg/kg/day; p.o.; 4 months) exhibits a chronic anti-hypertension effects in rats, results in blood pressure decreasing[3].
Trandolapril hydrochloride (0.25 mg/kg; p.o.; twice a day; 4 months) inhibits Atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: UUD (unilateral ureteral obstruction) model in Male CD-1 mice (18-22 g)[2]
Dosage: 3 mg/kg
Administration: Oral gavage; daily, for 7 days
Result: Resulted in renal interstitial matrix expression (including fibronectin, type I, and type III collagen) decreasing, and inhibited myofibroblast activation by surprising a-smooth muscle actin (a-SMA) expression, decreased the RANTES (regulated on activation, normal T cell expressed and secreted) and TNF-α level.
Animal Model: SHR model (spontaneously hypertensive rats, 4-week-old)[3]
Dosage: 0.3 mg/kg
Administration: Oral gavage; daily for 4 weeks
Result: Reduced collagen content in the aortic media and increased ariterial distensibility up to about 80%.
Animal Model: Watanabe heritable hyperlipidemic rabbit (3 months old)[4]
Dosage: 0.25 mg/kg
Administration: Oral gavage; twice a day; 9 months
Result: Decreased in atherosclerotic involvement of the intimal surface, and also decreased cholesterol content in descending thoracic aorta.
Clinical Trial
Molecular Weight

467.00

Formula

C24H35ClN2O5
CAS No.
SMILES

O=C([C@H]1N(C([C@@H](N[C@H](C(OCC)=O)CCC2=CC=CC=C2)C)=O)[C@@]3([H])CCCC[C@]3([H])C1)O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Trandolapril hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trandolapril87725-72-2RU44570RU 44570RU-44570Angiotensin-converting Enzyme (ACE)congestive heart failureCHFmyocardial infarctionMITrandolapril hydrochlorideatorally activehypertensionnonsulfhydrylarterial hypertrophycollagencellular fibronectin accumulationspontaneously hypertensive ratsUUD modelunilateral ureteral obstructionUUO modelInhibitorinhibitorinhibit

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