2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. trans-J-113863

trans-J-113863 is a potent chemokine CCR1 and CCR3 receptor antagonist, and inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants with IC50 of 9.57 and 93.8 nM,respectively.

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trans-J-113863 Chemical Structure

trans-J-113863 Chemical Structure

CAS No. : 202796-42-7

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Description

trans-J-113863 is a potent chemokine CCR1 and CCR3 receptor antagonist, and inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants with IC50 of 9.57 and 93.8 nM,respectively[1][2].

Molecular Weight

655.44

Formula

C30H37Cl2IN2O2
CAS No.
SMILES

CC[N@+]1(C/C2=C/CCCCCC2)CC[C@H](NC(C3C4=C(OC5=C3C=C(Cl)C=C5)C=CC(Cl)=C4)=O)CC1.[I-]
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Room temperature in continental US; may vary elsewhere.
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trans-J-113863 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

trans-J-113863202796-42-7CCRCC chemokine receptorasthmavirus-1inflammatory diseaseInhibitorinhibitorinhibit

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