2. Apoptosis Autophagy
  3. MDM-2/p53 Autophagy Apoptosis
  4. TRAP-1

TRAP-1 (XJZ-06-462) is ap53 transcriptional activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. TRAP-1 rapidly upregulates p21 and other p53 target genes in pancreatic cell lines with p53Y220C. TRAP-1 inhibits cell proliferation, with IC50 values of 3.94 and 0.531 μM in BxPC-3 and A549 cells, respectively. TRAP-1 regulates autophagy in lung cancer cells and offers protective effects against oxidative stress and cell apoptosis.

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TRAP-1 Chemical Structure

TRAP-1 Chemical Structure

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TRAP-1 Related Antibodies

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Description

TRAP-1 (XJZ-06-462) is ap53 transcriptional activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. TRAP-1 rapidly upregulates p21 and other p53 target genes in pancreatic cell lines with p53Y220C. TRAP-1 inhibits cell proliferation, with IC50 values of 3.94 and 0.531 μM in BxPC-3 and A549 cells, respectively. TRAP-1 regulates autophagy in lung cancer cells and offers protective effects against oxidative stress and cell apoptosis[1][2][3].

Molecular Weight

1108.69

Formula

C57H66ClF3N11O3PS
SMILES

O=C(N1CCN(CC2CCN(C(CN3CCC(NC4=CC=CC5=C4C=C(C#CCNC6=CC=C(P(C)(C)=O)C=C6)N5CC(F)(F)F)CC3)=O)CC2)CC1)C[C@H]7C8=NN=C(C)N8C9=C(C(C)=C(C)S9)C(C%10=CC=C(Cl)C=C%10)=N7
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Room temperature in continental US; may vary elsewhere.
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TRAP-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRAP-1XJZ-06-462TRAP1TRAP 1MDM-2/p53AutophagyApoptosisp53Y220Cp53p21BxPC-3A549oxidative stressInhibitorinhibitorinhibit

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