2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. TRAP1-IN-2

TRAP1-IN-2 (compound 36) is a selective degrader of TRAP1 downstream proteins without affecting Hsp90's cytoplasmic downstream proteins. TRAP1-IN-2 also inhibits OXPHOS and alters cellular glycolysis metabolism. TRAP1-IN-2 destabilizes TRAP1 tetramers and disrupts mitochondrial membrane potential.

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TRAP1-IN-2 Chemical Structure

TRAP1-IN-2 Chemical Structure

CAS No. : 3031102-92-5

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TRAP1-IN-2 Related Antibodies

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Description

TRAP1-IN-2 (compound 36) is a selective degrader of TRAP1 downstream proteins without affecting Hsp90's cytoplasmic downstream proteins. TRAP1-IN-2 also inhibits OXPHOS and alters cellular glycolysis metabolism. TRAP1-IN-2 destabilizes TRAP1 tetramers and disrupts mitochondrial membrane potential.

IC50 & Target

TRAP1
Molecular Weight

878.77

Formula

C46H42F6N2O5P2
CAS No.
SMILES

O=C(C1=C(O)C=CC(C(N2CC(C(OC)=CC=C3)=C3C2)=O)=C1)N(C4)CC5=C4C=CC(OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)=C5.F[P-](F)(F)(F)(F)F
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TRAP1-IN-2 Related Classifications

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Keywords:

TRAP1-IN-23031102-92-5HSPHeat shock proteinsTRAP1 client proteinHsp90-cytosolic clientsOXPHOSglycolysisTRAP1 tetramer stabilitymitochondrial membrane potentialInhibitorinhibitorinhibit

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